Water Soluble CBD

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water soluable cbd

Unlike regular water soluable cbd oil, which loses much of its beneficial compounds during digestion, water-soluble cbd can be ingested and absorbed directly into your bloodstream. This type of oil is also more versatile, as you can mix it into any beverage or food that contains water. For example, you can take it in a smoothie or even bake with it.

A novel formulation of chitosan-based nanocarriers loaded with CBD was developed to increase the solubility of the drug. The CBD encapsulation efficiency was determined by performing a binding test on a sample of the nanocarriers. It was found that a high percentage of the CBD could be encapsulated by the chitosan-CBD complex.

The Science Behind Water-Soluble CBD: A Deep Dive

The chitosan-CBD complex showed an average diameter of 22.5 nm and a specific surface area of 357 m2 g1. The nanocarriers were stabilized with lecithin or HPMCAS, which resulted in different CBD release kinetics. The lecithin-stabilized nanoparticles exhibited an immediate complete burst release, while the HPMCAS-stabilized particles demonstrated a slow and gradual release. Both nanoformulations exhibited superior dissolution in comparison with the bulk crystalline CBD.

The nasal administration of the CBD solution produced an antinociceptive effect in mice with neuropathic pain (p 0.001). The activity persisted for more than 6 hours. In addition, the CBD solution induced a significant reduction in paw irritation in mice following a thermal burn. The pharmacological effects of the CBD solution may be related to the activation of peroxisome proliferator-activated receptors (PPAR) in cells. PPAR-gamma activation reduces the accumulation of beta-amyloid plaque and regulates genes involved in energy homeostasis, lipid uptake, and insulin sensitivity.

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